Document image translation (DIT) aims to translate text embedded in images from one language to another. It is a challenging task that needs to understand visual layout with text semantics simultaneously. However, existing methods struggle to capture the crucial visual layout in real-world complex document images. In this work, we make the first attempt to incorporate layout knowledge into DIT in an end-to-end way. Specifically, we propose a novel Layout-aware end-to-end Document Image Translation (LayoutDIT) with multi-step conductive decoder. A layout-aware encoder is first introduced to model visual layout relations with raw OCR results. Then a novel multi-step conductive decoder is unified with hidden states conduction across three step-decoders to achieve the document translation step by step. Benefiting from the layout-aware end-to-end joint training, our LayoutDIT outperforms state-of-the-art methods with better parameter efficiency. Besides, we create a new multi-domain document image translation dataset to validate the model’s generalization. Extensive experiments show that LayoutDIT has a good generalization in diverse and complex layout scenes.