Boosting Transformers and Language Models for Clinical Prediction in Immunotherapy

Zekai Chen, Mariann Micsinai Balan, Kevin Brown


Abstract
Clinical prediction is an essential task in the healthcare industry. However, the recent success of transformers, on which large language models are built, has not been extended to this domain. In this research, we explore the use of transformers and language models in prognostic prediction for immunotherapy using real-world patients’ clinical data and molecular profiles. This paper investigates the potential of transformers to improve clinical prediction compared to conventional machine learning approaches and addresses the challenge of few-shot learning in predicting rare disease areas. The study benchmarks the efficacy of baselines and language models on prognostic prediction across multiple cancer types and investigates the impact of different pretrained language models under few-shot regimes. The results demonstrate significant improvements in accuracy and highlight the potential of NLP in clinical research to improve early detection and intervention for different diseases.
Anthology ID:
2023.acl-industry.32
Volume:
Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 5: Industry Track)
Month:
July
Year:
2023
Address:
Toronto, Canada
Editors:
Sunayana Sitaram, Beata Beigman Klebanov, Jason D Williams
Venue:
ACL
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
332–340
Language:
URL:
https://aclanthology.org/2023.acl-industry.32
DOI:
10.18653/v1/2023.acl-industry.32
Bibkey:
Cite (ACL):
Zekai Chen, Mariann Micsinai Balan, and Kevin Brown. 2023. Boosting Transformers and Language Models for Clinical Prediction in Immunotherapy. In Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 5: Industry Track), pages 332–340, Toronto, Canada. Association for Computational Linguistics.
Cite (Informal):
Boosting Transformers and Language Models for Clinical Prediction in Immunotherapy (Chen et al., ACL 2023)
Copy Citation:
PDF:
https://aclanthology.org/2023.acl-industry.32.pdf